Real-time vascular mechanosensation through ex vivo artery perfusion
نویسندگان
چکیده
منابع مشابه
Ex vivo lung perfusion in Brazil
OBJECTIVE To evaluate the use of ex vivo lung perfusion (EVLP) clinically to prepare donor lungs for transplantation. METHODS A prospective study involving EVLP for the reconditioning of extended-criteria donor lungs, the criteria for which include aspects such as a PaO2/FiO2 ratio < 300 mmHg. Between February of 2013 and February of 2014, the lungs of five donors were submitted to EVLP for u...
متن کاملEx vivo lung perfusion: initial Brazilian experience* Perfusão pulmonar ex vivo: experiência nacional inicial
In the last 20 years, lung transplantation has become the standard treatment for patients with end-stage lung disease. However, less than 20% of the donor lungs available for transplant are actually usable. This disparity between the growing number of recipients and the small number of donors has resulted in increased mortality among lung transplant candidates on waiting lists. Strategies such ...
متن کاملBiomechanics of vascular mechanosensation and remodeling
Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that line the blood and lymphatic vessels. The magnitude, pulsatility, and directional characteristics of FSS are constantly sensed by the endothelium. Sustained increases or decreases in FSS induce vessel remodeling to maintain proper perfusion of tissue. In this review, we discuss these mechanisms and ...
متن کاملEx vivo perfusion, arteriography, and autotransplantation procedures for kidney salvage.
NOT UNCO MMONLY, the need arises for renal arterial surgical procedures but under conditions which would make the use of ordinary vascular reconstructive techniques difficult or impossible, as for example with distally located fibromuscular dysplasia or hilar aneurysm. This study was undertaken to descri be a method of renal au totransplantation by which a kidney can be removed, cooled, perfuse...
متن کاملAntagonizing reactive oxygen species during ex vivo lung perfusion.
TO THE EDITOR: The stop of flow (ischemia) would be interpreted as membrane depolarization, through the inhibition of KATP channels, leading to activation of NADPH oxidase, leading to increased reactive oxygen species (ROS) production (1). The resultant ROS are claimed to be an effective mediator for ischemic preconditioning (IPC), as proved by the observation that the presence of antioxidants ...
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ژورنال
عنوان ژورنال: Biological Procedures Online
سال: 2014
ISSN: 1480-9222
DOI: 10.1186/1480-9222-16-6